Table of Contents
VOLUME 1
PREFACE … v
FOR YOUR REFERENCE … ix
LIST OF CONTRIBUTORS … xvii
A
Accelerated Aging: Progeria … 1
Addiction … 4
Aging and Life Span … 6
Agricultural Biotechnology … 9
Alternative Splicing … 11
Alzheimer's Disease … 14
Ames Test … 19
Androgen Insensitivity Syndrome … 21
Antibiotic Resistance … 26
Antisense Nucleotides … 29
Apoptosis … 31
Arabidopsis thaliana … 33
Archaea … 36
Attention Deficit Hyperactivity Disorder … 39
Attorney … 42
Automated Sequencer … 43
B
Balanced Polymorphism … 45
Behavior … 46
Bioinformatics … 52
Biopesticides … 57
Bioremediation … 59
Biotechnology … 62
Biotechnology Entrepreneur … 65
Biotechnology: Ethical Issues … 66
Biotechnology and Genetic Engineering, History … 70
Birth Defects … 74
Blood Type … 82
Blotting … 86
Breast Cancer … 89
C
Cancer … 92
Carcinogens … 97
Cardiovascular Disease … 101
Cell Cycle … 103
Cell, Eukaryotic … 108
Centromere … 114
Chaperones … 116
Chromosomal Aberrations … 119
Chromosomal Banding … 125
Chromosomal Theory of Inheritance, History … 129
Chromosome, Eukaryotic … 132
Chromosome, Prokaryotic … 139
Chromosomes, Artificial … 144
Classical Hybrid Genetics … 146
Clinical Geneticist … 149
Cloning Genes … 152
Cloning: Ethical Issues … 158
Cloning Organisms … 161
College Professor … 165
Colon Cancer … 166
Color Vision … 170
Combinatorial Chemistry … 173
Complex Traits … 177
Computational Biologist … 181
Conjugation … 182
Conservation Biology: Genetic Approaches … 186
Conservation Geneticist … 190
Crick, Francis … 192
Crossing Over … 194
Cycle Sequencing … 198
Cystic Fibrosis … 199
D
Delbrück, Max … 203
Development, Genetic Control of … 204
Diabetes … 209
Disease, Genetics of … 213
DNA … 215
DNA Footprinting … 220
DNA Libraries … 222
DNA Microarrays … 225
DNA Polymerases … 230
DNA Profiling … 233
DNA Repair … 239
DNA Structure and Function, History … 248
DNA Vaccines … 253
Down Syndrome … 256
PHOTO CREDITS … 259
GLOSSARY … 263
TOPICAL OUTLINE … 281
INDEX … 287
VOLUME 2
FOR YOUR REFERENCE … v
LIST OF CONTRIBUTORS … xiii
E
Educator … 1
Embryonic Stem Cells … 3
Epidemiologist … 6
Epistasis … 7
Escherichia coli (E. coli bacterium) … 9
Eubacteria … 11
Eugenics … 16
Evolution, Molecular … 21
Evolution of Genes … 26
Eye Color … 31
F
Fertilization … 33
Founder Effect … 36
Fragile X Syndrome … 39
Fruit Fly: Drosophila … 42
G
Gel Electrophoresis … 45
Gene … 50
Gene and Environment … 54
Gene Discovery … 57
Gene Expression: Overview of Control … 61
Gene Families … 67
Gene Flow … 70
Gene Targeting … 71
Gene Therapy … 74
Gene Therapy: Ethical Issues … 80
Genetic Code … 83
Genetic Counseling … 87
Genetic Counselor … 91
Genetic Discrimination … 92
Genetic Drift … 94
Genetic Testing … 96
Genetic Testing: Ethical Issues … 101
Genetically Modified Foods … 106
Geneticist … 110
Genetics … 111
Genome … 112
Genomic Medicine … 118
Genomics … 120
Genomics Industry … 123
Genotype and Phenotype … 125
Growth Disorders … 129
H
Hardy-Weinberg Equilibrium … 133
Hemoglobinopathies … 136
Hemophilia … 141
Heterozygote Advantage … 146
High-Throughput Screening … 149
HIV … 150
Homology … 156
Hormonal Regulation … 158
HPLC: High-Performance Liquid
Chromatography … 165
Human Disease Genes, Identification of … 167
Human Genome Project … 171
Human Immunodeficiency Virus … 178
Huntington's Disease … 178
Hybrid Superiority … 178
I
Immune System Genetics … 178
Imprinting … 183
In situ Hybridization … 186
Inbreeding … 189
Individual Genetic Variation … 191
Information Systems Manager … 192
Inheritance, Extranuclear … 194
Inheritance Patterns … 199
Intelligence … 207
Internet … 211
PHOTO CREDITS … 215
GLOSSARY … 219
TOPICAL OUTLINE … 237
INDEX … 243
VOLUME 3
FOR YOUR REFERENCE … v
LIST OF CONTRIBUTORS … xiii
L
Laboratory Technician … 1
Legal Issues … 3
Linkage and Recombination … 4
M
Maize … 8
Mapping … 11
Marker Systems … 15
Mass Spectrometry … 18
McClintock, Barbara … 21
McKusick, Victor … 22
Meiosis … 24
Mendel, Gregor … 30
Mendelian Genetics … 32
Metabolic Disease … 37
Methylation … 46
Microbiologist … 50
Mitochondrial Diseases … 51
Mitochondrial Genome … 55
Mitosis … 57
Model Organisms … 60
Molecular Anthropology … 62
Molecular Biologist … 70
Morgan, Thomas Hunt … 72
Mosaicism … 76
Muller, Hermann … 80
Multiple Alleles … 82
Muscular Dystrophy … 83
Mutagen … 87
Mutagenesis … 89
Mutation … 93
Mutation Rate … 98
N
Nature of the Gene, History … 101
Nomenclature … 106
Nondisjunction … 108
Nucleases … 112
Nucleotide … 115
Nucleus … 119
O
Oncogenes … 127
Operon … 131
Overlapping Genes … 135
P
Patenting Genes … 136
Pedigree … 138
Pharmaceutical Scientist … 142
Pharmacogenetics and Pharmacogenomics … 144
Physician Scientist … 147
Plant Genetic Engineer … 149
Plasmid … 150
Pleiotropy … 153
Polymerase Chain Reaction … 154
Polymorphisms … 159
Polyploidy … 163
Population Bottleneck … 167
Population Genetics … 171
Population Screening … 175
Post-translational Control … 178
Prenatal Diagnosis … 182
Prion … 187
Privacy … 190
Probability … 193
Protein Sequencing … 196
Proteins … 198
Proteomics … 205
Pseudogenes … 209
Psychiatric Disorders … 213
Public Health, Genetic Techniques in … 216
Purification of DNA … 220
PHOTO CREDITS … 223
GLOSSARY … 227
TOPICAL OUTLINE … 245
INDEX … 251
VOLUME 4
FOR YOUR REFERENCE … v
LIST OF CONTRIBUTORS … xiii
Q
Quantitative Traits … 1
R
Reading Frame … 4
Recombinant DNA … 5
Repetitive DNA Sequences … 7
Replication … 12
Reproductive Technology … 19
Reproductive Technology: Ethical Issues … 26
Restriction Enzymes … 31
Retrovirus … 34
Reverse Transcriptase … 39
Ribosome … 42
Ribozyme … 44
RNA … 46
RNA Interference … 54
RNA Processing … 57
Rodent Models … 60
Roundworm: Caenorhabditis elegans … 62
S
Sanger, Fred … 64
Science Writer … 65
Selection … 67
Sequencing DNA … 69
Severe Combined Immune Deficiency … 74
Sex Determination … 78
Sexual Orientation … 83
Signal Transduction … 85
Speciation … 91
Statistical Geneticist … 93
Statistics … 95
T
Tay-Sachs Disease … 98
Technical Writer … 102
Telomere … 104
Transcription … 106
Transcription Factors … 112
Transduction … 117
Transformation … 121
Transgenic Animals … 124
Transgenic Microorganisms … 127
Transgenic Organisms: Ethical Issues … 129
Transgenic Plants … 132
Translation … 135
Transplantation … 139
Transposable Genetic Elements … 143
Triplet Repeat Disease … 148
Tumor Suppressor Genes … 153
Twins … 155
V
Viroids and Virusoids … 162
Virus … 164
W
Watson, James … 171
X
X Chromosome … 173
Y
Y Chromosome … 176
Yeast … 179
Z
Zebrafish … 181
PHOTO CREDITS … 185
GLOSSARY … 189
TOPICAL OUTLINE … 207
CUMULATIVE INDEX … 213
